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Author: Admin | 2025-04-28
Of achieving prompt blood pressure control exceeds the risk of initiating combination therapy.SEVERE HYPERTENSION:Initial treatment: Hydrochlorothiazide 12.5 mg-Losartan 50 mg orally once a day; if blood pressure remains uncontrolled after 2 to 4 weeks, may initiate maximum dose.Maximum dose: Hydrochlorothiazide 25 mg-Losartan 100 mg orally once a dayHYPERTENSION WITH LEFT VENTRICULAR HYPERTROPHY:Initial therapy: Losartan monotherapy; if blood pressure remains uncontrolled, may initiate this drug.Add-on therapy: Hydrochlorothiazide 12.5 mg-Losartan 50 mg orally once a day; if blood pressure remains uncontrolled, initiate hydrochlorothiazide 12.5 mg-losartan 100 mg orally once a day, followed by hydrochlorothiazide 25 mg-losartan 100 mg orally once a day, if needed.Use: To reduce the risk of stroke in patients with hypertension and left ventricular hypertrophy, but there is evidence that this benefit does not apply to Black patients.What happens if I miss a dose?Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.What happens if I overdose?Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.What should I avoid while taking hydrochlorothiazide and losartan?Hydrochlorothiazide may increase your risk of skin cancer. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. Your doctor may want you to have skin examinations on a regular basis.Do not use potassium supplements or salt substitutes, unless your doctor has told you to.Drinking alcohol can further lower your blood pressure and may cause side effects.Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids.What other drugs will affect hydrochlorothiazide and losartan?If you also take cholestyramine or colestipol, take your hydrochlorothiazide and losartan dose 4 hours before or 4 to 6 hours after you take the other medicine.Tell your doctor about all your other medicines, especially:a diuretic or "water pill";other blood pressure medications;lithium; orNSAIDs (nonsteroidal anti-inflammatory drugs)--aspirin, ibuprofen (Advil, Motrin), naproxen (Aleve), celecoxib, diclofenac, indomethacin, meloxicam, and others.This list is not complete. Other drugs may affect hydrochlorothiazide and losartan, including prescription and over-the-counter medicines, vitamins, and herbal products.
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