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Author: Admin | 2025-04-28
ContentsWhat is TenorminTenormin mechanism of actionWhat is tenormin used for?Tenormin special precautionsContraindicationsPregnancyBreastfeedingDrug InteractionsOther medical problemsTenormin dosageHypertensionAngina PectorisAcute Myocardial InfarctionWhat should I do if I forget a dose?Tenormin side effectsWhat is TenorminTenormin is a brand name of a second generation cardioselective beta-blocker called atenolol, that is used in the treatment of hypertension (high blood pressure), angina pectoris (heart chest pain) and acute myocardial infarction (heart attack). Tenormin is also used to lower the risk of death after a heart attack. Non-FDA approved indications include treatment of arrhythmias (irregular heartbeat), migraine prophylaxis, paroxysmal supraventricular tachycardia, alcohol withdrawal, thyrotoxicosis and prophylaxis against secondary myocardial infarction 1. Tenormin (atenolol) works by relaxing blood vessels and slowing heart rate to improve blood flow and decrease blood pressure.Tenormin (atenolol) was approved for use in the United States in 1981 and is still widely used in the therapy of hypertension and angina pectoris. Tenormin (atenolol) is also used to reduce the risk of cardiovascular mortality in patients with coronary artery disease.Tenormin (atenolol) is considered a “selective” beta-adrenergic receptor blocker in that it has potent activity against beta-1 adrenergic receptors which are found in cardiac muscle, but has little or no activity against beta-2 adrenergic receptors found on bronchial and vascular smooth muscle.Tenormin (atenolol) is available in 25, 50 and 100 mg tablets in generic forms as well as under the trade name of Tenormin. It is also available in fixed combinations with a diuretic such as chlorthalidone (Tenoretic and others). Parenteral formulations for intravenous use are also available. The usual oral dose of tenormin (atenolol) in adults is 25 to 50 mg once daily initially, with subsequent adjustment based upon clinical response and tolerance, but rarely beyond 100 mg daily.Tenormin (atenolol) controls high blood pressure and angina but does not cure them. It may take 1-2 weeks before you feel the full benefit of tenormin (atenolol). Continue to take tenormin (atenolol) even if you feel well. Do not stop taking tenormin (atenolol) without talking to your doctor.Tenormin (atenolol) common side effects include bradycardia, hypotension, fatigue, dizziness, depression, memory loss and impotence. At high doses, tenormin (atenolol) is less cardioselective and can cause bronchospasm. As with all beta-blockers, sudden withdrawal can trigger rebound hypertension.IMPORTANT WARNINGDo not stop taking Tenormin (atenolol) without talking to your doctor. Suddenly stopping Tenormin (atenolol) may cause chest pain, heart attack, or irregular heartbeat. Your doctor will probably decrease your dose gradually.Tenormin mechanism of actionCardioselective beta-1-adrenergic antagonists such as Tenormin (atenolol) work by selectively binding to the beta-1 adrenergic receptors found in vascular smooth muscle and the heart, blocking the positive inotropic and chronotropic actions of endogenous catecholamines such as isoproterenol, norepinephrine, and epinephrine, thereby inhibiting sympathetic stimulation 2. This activity results in a
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