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Author: Admin | 2025-04-28
Treating mood disorders, the drug would not be discontinued unless the psoriasis symptoms are unmanageable.Stopping a MedicationThough a drug may very well be impacting your psoriasis, never stop taking a prescribed medication without consulting your healthcare provider. Instead, contact your rheumatologist or dermatologist to schedule a complete evaluation. If a drug is identified as the culprit, the dose may be adjusted or treatment stopped based on symptoms and/or medical needs. Antimalarials Used to treat malaria as well as rheumatoid arthritis and lupus, antimalarial drugs are known to induce and aggravate psoriasis. Of the antimalarials commonly implicated, Plaquenil (hydroxychloroquine) and chloroquine pose the greatest risk. Most flares develop within weeks of starting treatment. Chloroquine is closely linked to plaque psoriasis and pustular psoriasis. Both drugs are also known to prolong flares for months (particularly if there has been a pustular eruption). Chloroquine is also believed to exacerbate symptoms of psoriatic arthritis. Once antimalarial treatment has been stopped, it may take up to a month for the psoriasis symptoms to resolve. Because of this, such drugs should not be taken by those with psoriasis. Interferons Interferons are a class of drug often used to treat hepatitis C and other diseases. Both interferon-alpha and interferon-beta have well-known associations with psoriasis. Interferon-alpha, used to treat viral hepatitis, leukemia, kidney, cancer, and melanoma, is linked to plaque psoriasis and, to a lesser degree, psoriatic arthritis. Interferon-beta, used for multiple sclerosis, can induce a new psoriasis outbreak or exacerbate existing symptoms. Generally speaking, if interferon-alpha or interferon-beta is indicated for treatment, it would only be discontinued if the psoriatic symptoms are intolerable. Terbinafine Terbinafine is a synthetic antifungal used to treat athlete's foot, jock itch, and other common fungal skin infections. Available in both topical and oral formulations, terbinafine has been linked to more widespread psoriatic flares. These most commonly occur with the oral version, known by the brand name Lamisil, which can induce or exacerbate plaque psoriasis, generalized (all-body) pustular psoriasis, and inverse psoriasis. Topical preparations can do the same, most often in the region of drug application. ACE Inhibitors Angiotensin-converting enzyme (ACE) inhibitors like Lotensin (benazepril) and Vasotec (enalapril) are used to control hypertension. Their association with psoriasis is less certain, although people over 50 appear to be at greatest risk. While ACE inhibitors are believed to induce or exacerbate psoriasis, there is evidence that the effect may be limited to people with a family history of psoriasis and specific genetic subtypes of the angiotensin-converting enzyme. If a flare were to occur after taking an ACE inhibitor, the decision to continue or discontinue the drug would be made by a healthcare provider on a case-by-case basis. TNF Blockers Tumor necrosis factor (TNF) alpha antagonists, also known as TNF blockers, are a type of biologic drug used to treat Crohn’s disease, rheumatoid arthritis, and ankylosing spondylitis. They work by suppressing the production of TNF, a type of inflammatory compound closely linked to autoimmune diseases. These include such drugs as: Humira (adalimumab)Enbrel (etanercept)Remicade (infliximab) The triggering
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