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Author: Admin | 2025-04-28
Production of peripheral neurotransmitters.Nausea & vomiting: Nausea is a common symptom of omeprazole withdrawal that can be caused by rebound acid hypersecretion. In other words, because stomach enzymes are producing more acid than they did while using the medication, this sudden increase in acidification induces acid reflux, indigestion, and predictably – nausea. Although nausea in withdrawal is generally manageable, in severe cases it might lead to vomiting.Shakiness or trembling: According to anecdotal reports published online, one of the most common symptoms of omeprazole discontinuation is shakiness or trembling. Many report that their body constantly shakes or trembles uncontrollably for the first week or two after omeprazole cessation. If you’re experiencing extreme shakes, this could be a sign that you need to taper off of omeprazole at a slower rate.Stomach aches: If the medical condition for which omeprazole was originally prescribed resurfaces in withdrawal and/or you experience a transient spike in gastric acid production – this could certainly cause stomach aches. The stomach aches or pains that have been reported in omeprazole withdrawal could be relatively severe. Although dietary modifications and supplements might help, anyone experiencing debilitating stomach pain after stopping omeprazole should seek medical attention.Weight change: Body weight fluctuations can occur after stopping omeprazole for a variety of reasons. If you experience any significant increase or decrease in appetite during withdrawal, this will likely influence how much food you consume – and could explain your weight change. Other withdrawal symptoms like bloating and constipation might induce a transient, modest weight increase – whereas withdrawal symptoms like diarrhea might yield transient weight loss.Note: The above list of withdrawal symptoms associated with omeprazole might be incomplete. If you happen to know of additional symptoms that might occur following omeprazole discontinuation, report them in the comments section below.Contrasting: Omeprazole withdrawal symptoms vs. Medical conditionIt is important to emphasize that it’s often difficult to distinguish between omeprazole withdrawal symptoms and a relapse of the medical condition(s) for which omeprazole was prescribed to treat. For example, in someone with gastroesophageal reflux disease (GERD), discontinuation of omeprazole will likely result in the resurfacing of unmanaged GERD symptoms.In this hypothetical example, the individual with GERD may experience withdrawal symptoms due to omeprazole discontinuation, however, it may be impossible to differentiate withdrawal symptoms from a resurgence of GERD symptoms. This is because omeprazole discontinuation is hypothesized to provoke “rebound acid hypersecretion” (RAH).In other words, a greater amount of
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