Comment
Author: Admin | 2025-04-28
Which in turn decreases the coalescence rate and increases the thermodynamic stability of the system [11]. 3.6. Nebulization Performance of TD-Loaded NEsIn the current work, targeted delivery of TD to the lungs via inhalation was chosen for the treatment of pediatric PAH since it is believed that inhalation therapy offers many privileges over oral delivery in case of respiratory diseases, as previously mentioned. Three categories of inhalation devices are available, among which nebulizers were the first developed devices for pulmonary application [25]. Nebulizers possess many merits, including being advantageous in case of diseases requiring high pulmonary doses, and they are useful for patients who cannot achieve sufficient coordination necessary during the use of other devices (e.g., pediatric patients) [66]. For the latter reason, nebulizers were selected in the current investigation.Nebulizers act through the aerosolization of drug solutions. In order to guarantee therapeutic comfort, two substantial parameters, aerosol output, and aerosol output rate were taken into consideration [10]. Results showed that the aerosol output varied between 94.4 and 96.8% for the three formulations (Table 6). The amount of fluid delivered by the nebulizer is referred to as ‘aerosol output’ [67]. It is important that the aerosol output is high; otherwise, a fraction of the medical fluid originally loaded into the nebulizer will remain as ‘residual volume’ within the device by the end of the nebulization period, reducing the net therapeutic benefit [67]. The high values of the aerosol output achieved in the current study indicate that the jet nebulizer employed was
Add Comment