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Author: Admin | 2025-04-28
We need you! See something you could improve? Make an edit and help make WikEM better for everyone. GeneralType: Corticosteroids, systemicDosage Forms:1, 2, 5, 10, 20, 50, 5/5mlCommon Trade Names: Sterapred, Sterapred DS, RayosAdult DosingFor all doses of prednisone, it is best given with food. Also, ideally best when given in AM to coincide with natural cortisol release. No need to taper if short course less than 1 week, otherwise consider taper.Corticosteroid-responsive conditions5-60mg PO QDDose varies based on conditionAsthma, acute40-80mg/day PO divided QD-bid (most practitioners give 60mg po x 1 to 80-100kg adult)If patient can tolerate PO, no need to give steroids IV, but if asthma is severe, and bipap / intubation likely, best to keep patient NPO and give methylprednisolone IVAdrenal Insufficiency4-5mg/ m^2 PO QDTaper dose gradually to discharge when appropriateMultiple Sclerosis, acute exacerbation200mg PO QD x1 week, then 80mg po qod x1 moGive with food, also prescribe PPI for gastric protection. Taper dose gradually to dischargeAlcoholic Hepatitis, acute40mg PO QDPCP, Adjunct treatment40mg PO BID x5 days, then 40mg PO QD x5 days, then 20mg PO QD x11 daysStart within 72hrs of antimicrobial treatmentAlways consider discussion with HIV consultants prior to given steroids, as they will be managing patient in hospitalPediatric DosingFor all doses of prednisone, it is best tolerated with food. Ideally best when given in AM to coincide with natural cortisol release. No need to taper if short course less than 1 week, otherwise consider taper.Corticosteroid-responsive conditions0.05-2mg/kg/day PO divided QD-QIDDose varies based on conditionAsthma, acute1-2mg/day PO divided QD-bid Max 60mg/dayIf patient can tolerate PO, no need to give steroids IV, but if asthma is severe, and Bipap / intubation likely, best to keep patient NPO and give methylprednisolone IVAdrenal Insufficiency4-5mg/ m^2 PO QD Taper dose gradually to discharge when appropriateNephrotic Syndrome2mg / kg PO QDMax 80mg / day. Use for 1st 3 episodesPCP, adjunct treatment (children 1mg/kg PO BID x5days, then 0.5mg/kg PO BID x5days, then 0.5mg PO QD x 11 days. Start within 72 hrs of antimicrobial treatment (Children >40kg)40mg PO BID x5 days, then 20mg PO BID x5 days, then 20mg PO QD x 11
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