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Author: Admin | 2025-04-28
Concentration in plasma; therefore, additional doses are not necessary after hemodialysis. Meloxicam is not dialyzable [see WARNINGS AND PRECAUTIONS, CLINICAL PHARMACOLOGY]. Overdose Information for Meloxicam TabletsSymptoms following acute NSAID overdosages have been typically limited to lethargy, drowsiness, nausea, vomiting, and epigastric pain, which have been generally reversible with supportive care. Gastrointestinal bleeding has occurred. Hypertension, acute renal failure, respiratory depression, and coma have occurred, but were rare [see WARNINGS AND PRECAUTIONS].There is limited experience with meloxicam overdose. In four reported cases of meloxicam overdose, patients took 6 to 11 times the highest available dose of meloxicam tablets (15 mg); all recovered. Cholestyramine is known to accelerate the clearance of meloxicam.Manage patients with symptomatic and supportive care following an NSAID overdosage. There are no specific antidotes. Consider emesis and/or activated charcoal (60 to 100 grams in adults, 1 to 2 grams per kg of body weight in pediatric patients) and/or osmotic cathartic in symptomatic patients seen within four hours of ingestion or in patients with a large overdosage (5 to 10 times the recommended dosage). Accelerated removal of meloxicam by 4 g oral doses of cholestyramine given three times a day was demonstrated in a previous clinical trial. Forced diuresis, alkalinization of urine, hemodialysis, or hemoperfusion may not be useful due to high protein binding.For additional information about overdosage treatment contact a poison control center (1 800-222-1222).Contraindications for Meloxicam TabletsMeloxicam capsules are contraindicated in the following patients: Known hypersensitivity (e.g., anaphylactic reactions and serious skin reactions) to meloxicam or any components of the drug product [see WARNINGS AND PRECAUTIONS] History of asthma, urticaria, or other allergic-type reactions after taking aspirin or other NSAIDs. Severe, sometimes fatal, anaphylactic reactions to NSAIDs have been reported in such patients [see WARNINGS AND PRECAUTIONS] In the setting of coronary artery bypass graft (CABG) surgery [see WARNINGS AND PRECAUTIONS] Clinical Pharmacology for Meloxicam TabletsMechanism Of ActionMeloxicam is a nonsteroidal anti-inflammatory drug(NSAID) that exhibits anti-inflammatory, analgesic, and antipyretic activitiesin animal models. The mechanism of action of meloxicam, like that of otherNSAIDs, may be related to prostaglandin synthetase (cyclo-oxygenase)inhibition.PharmacokineticsAbsorptionThe absolute bioavailability of meloxicam capsules was89% following a single
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