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Author: Admin | 2025-04-28
Bile and gut where they undergo enterohepatic recirculation. Excretion Thyroid hormones are primarily eliminated by the kidneys. A portion of the conjugated hormone reaches the colon unchanged and is eliminated in the feces. Approximately 20% of T4 is eliminated in the stool. Urinary excretion of T4 decreases with age. Table 10. Pharmacokinetic Parameters of Thyroid Hormones in Euthyroid Patients Hormone Ratio in Thyroglobulin Biologic Potency t1/2 (days) Protein Binding (%) Includes TBG, TBPA, and TBA Levothyroxine (T4) 10-20 1 6-73 to 4 days in hyperthyroidism, 9 to 10 days in hypothyroidism 99.96 Liothyronine (T3) 1 4 ≤ 2 99.5 13 Nonclinical Toxicology 13.1 Carcinogenesis, Mutagenesis, Impairment of Fertility Long-term carcinogenicity studies in animals to evaluate the carcinogenic potential of levothyroxine have not been performed. Studies to evaluate mutagenic potential and animal fertility have not been performed. 16 How Supplied/storage And Handling How Supplied Levothyroxine Sodium Tablets, USP are available containing 25 mcg, 50 mcg, 75 mcg, 88 mcg, 100 mcg, 112 mcg, 125 mcg, 137 mcg, 150 mcg, 175 mcg, 200 mcg or 300 mcg of levothyroxine sodium, USP. They are available as follows: The 25 mcg tablets are orange, capsule-shaped, scored tablets debossed with L to the left of the score and 4 to the right of the score on one side of the tablet and M on the other side. NDC 0378-1800-77bottles of 90 tablets NDC 0378-1800-10bottles of 1000 tablets The 50 mcg tablets are white, capsule-shaped, scored tablets debossed with L to the left of the score and 5 to the right of the score on one side of the tablet and M on the other side. NDC 0378-1803-77bottles of 90 tablets NDC 0378-1803-10bottles of 1000 tablets The 75 mcg tablets are violet, capsule-shaped, scored tablets debossed with L to the left of the score and 6 to the right of the score on one side of the tablet and M on the other side. NDC 0378-1805-77bottles of 90 tablets NDC 0378-1805-10bottles of 1000 tablets The 88 mcg tablets are olive, capsule-shaped, scored tablets debossed with L to the left of the score and 7 to the right of the score on one side of the tablet and M on the other side. NDC 0378-1807-77bottles of 90 tablets NDC 0378-1807-10bottles of 1000 tablets The 100 mcg tablets are yellow, capsule-shaped, scored tablets debossed with L to the left of the score and 8 to the right of
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