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Author: Admin | 2025-04-28
With various medications, potentially leading to adverse effects or reduced efficacy. It’s essential to inform your healthcare provider about all medications you are taking, including prescription medications, over-the-counter drugs, supplements, and herbal products, to avoid potentially harmful interactions. Here are some medications that may interact with tramadol:Other Opioids: Concurrent use of tramadol with other opioids, such as morphine, oxycodone, or hydrocodone, can increase the risk of respiratory depression, sedation, and other central nervous system effects. Combining opioids can also increase the risk of dependence, addiction, and overdose.Benzodiazepines and CNS Depressants: Tramadol should not be used concurrently with benzodiazepines, such as diazepam or alprazolam, or other central nervous system depressants, such as sedatives, tranquilizers, or muscle relaxants. Combining tramadol with CNS depressants can lead to excessive sedation, respiratory depression, coma, and death.Serotonergic Medications: Tramadol has serotonergic properties and can increase serotonin levels in the brain. Concurrent use of tramadol with other serotonergic medications, such as selective serotonin reuptake inhibitors (SSRIs), serotonin-norepinephrine reuptake inhibitors (SNRIs), tricyclic antidepressants, or monoamine oxidase inhibitors (MAOIs), can increase the risk of serotonin syndrome, a potentially life-threatening condition characterized by agitation, hallucinations, rapid heart rate, high blood pressure, fever, sweating, tremors, and diarrhea.Monoamine Oxidase Inhibitors (MAOIs): Tramadol should not be used concurrently with MAOIs or within 14 days of discontinuing MAOI therapy. Combining tramadol with MAOIs can increase the risk of serotonin syndrome, hypertensive crisis, and other adverse effects.Antidepressants: Some antidepressant medications, such as tricyclic antidepressants (TCAs), SSRIs, and SNRIs, can increase the risk of serotonin syndrome
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