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Author: Admin | 2025-04-28
5 to 7 hours; increased half-life with decreased renal function; anuric adult patients: 132 hours; adults during hemodialysis: 3.8 hoursProtein Binding Use in Specific PopulationsSpecial Populations: Renal Function ImpairmentIn CrCl Use: Labeled IndicationsPostherpetic neuralgia: Management of postherpetic neuralgia (PHN) in adults.Seizures, focal (partial) onset (immediate release only): As adjunctive therapy in the treatment of focal (partial) seizures with and without secondary generalization in adults and pediatric patients 3 years of age and older with epilepsy. Use: Off LabelAlcohol use disorder, moderate to severe (alternative agent)byesData from randomized, double-blind, placebo-controlled studies support the use of gabapentin in the maintenance of abstinence in patients with alcohol use disorder Brower 2008, Furieri 2007, Mason 2014.Based on the American Psychiatric Association (APA) guidelines for the pharmacological treatment of patients with alcohol use disorder, gabapentin is suggested for patients with alcohol use disorder (moderate to severe) who want to decrease or abstain from use of alcohol and either prefer gabapentin or are unable to tolerate or are unresponsive to naltrexone and acamprosate APA [Reus 2018]. Based on the VA/DoD clinical practice guideline for the management of substance use disorders, gabapentin given for moderate to severe alcohol use disorder is effective and suggested when first-line pharmacotherapy is contraindicated or ineffective VA/DoD 2015.Alcohol withdrawal, mild (alternative agent)byesData from a randomized, double-blind, active-controlled study support the use of gabapentin in the outpatient treatment of mild alcohol withdrawal Myrick 2009. Similarly, a high heterogeneity meta-analysis that included only a limited number of randomized, controlled trials support the use of
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