Comment
Author: Admin | 2025-04-28
Be necessary; do not exceed maximum recommended bupropion dosage CimetidinePossible decreased metabolism of bupropion Use with cautionCorticosteroids (systemic)Possible lowering of seizure threshold; increased risk of seizures Use with extreme caution; initiate therapy with lower dosages and increase gradually DigoxinPossible decreased digoxin concentrations Monitor plasma digoxin concentrations EfavirenzPossible decreased bupropion exposure; hydroxybupropion exposure unchanged but peak concentration increased Increase in bupropion dosage may be necessary; do not exceed maximum recommended bupropion dosage LevodopaPotential increased incidence of adverse CNS effects (e.g., restlessness, agitation, tremor, ataxia, gait disturbance, vertigo, dizziness) Use concomitantly with caution LopinavirPossible decreased bupropion and hydroxybupropion exposure Increase in bupropion dosage may be necessary; do not exceed maximum recommended dosage MAO inhibitors (e.g., phenelzine)Possible enhanced acute toxicity of bupropion; increased risk of hypertensive reactions Concomitant use is contraindicated; ≥14 days should elapse between discontinuation of an MAO inhibitor and initiation of treatment with bupropion or between discontinuation of bupropion and initiation of an MAO inhibitor MAO inhibitors, reversible (e.g., linezolid, IV methylene blue)Possible increased risk of hypertensive reactions Do not initiate reversible MAO inhibitors in patients receiving bupropion If urgent treatment with a reversible MAO inhibitor is necessary (alternatives not available and possible benefits outweigh risks), discontinue bupropion prior to administering reversible MAO inhibitor; then, monitor patient for 2 weeks or until 24 hours after last dose of reversible MAO inhibitor; may resume bupropion 24 hours after last dose of reversible MAO inhibitor NelfinavirPossible decreased metabolism of bupropion NicotinePossible increased risk of hypertensionMonitor BPPhenobarbitalPossible increased metabolism of bupropion Increase in bupropion dosage may be necessary; do not exceed maximum recommended dosage PhenytoinPossible increased metabolism of bupropion Increase in bupropion dosage may be necessary; do not exceed maximum recommended dosage Platelet-aggregation inhibitors (e.g., clopidogrel, prasugrel, ticlopidine)Potential pharmacokinetic interaction (may increase bupropion exposure but decrease hydroxybupropion exposure) Adjust bupropion dosage if necessary
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