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Author: Admin | 2025-04-28
Herpes zoster, younger than 12 years with cold sores, younger than 2 years with chickenpox, or for suppressive treatment after neonatal HSV infection.Consult WARNINGS section for additional precautions.DialysisHemodialysis: The recommended dose should be administered after hemodialysis.Peritoneal dialysis: Data not availableChronic ambulatory peritoneal dialysis (CAPD) and continuous arteriovenous hemofiltration/dialysis (CAVHD): Supplemental doses should not be needed after CAPD or CAVHD.Comments:During hemodialysis, the acyclovir half-life after administration of this drug is about 4 hours; about one-third of acyclovir in the body is removed during a 4-hour hemodialysis session.No information specific to administration of this drug available in patients receiving peritoneal dialysis; the effect of CAPD and CAVHD on acyclovir pharmacokinetics (PKs) has been studied.Removal of acyclovir after CAPD and CAVHD is less pronounced than with hemodialysis; the PK parameters closely resemble those seen in patients with ESRD not receiving hemodialysis.Other CommentsAdministration advice:May administer without regard to mealsMaintain adequate hydration during therapy.An oral suspension may be prepared extemporaneously for use in pediatric patients for whom the solid dosage form is not appropriate; shake the oral suspension well prior to use.Consult the manufacturer product information regarding missed doses.Storage requirements:Oral suspension: Store between 2C to 8C (36F to 46F) in a refrigerator; discard after 28 days.Reconstitution/preparation techniques:Extemporaneous preparation of oral suspension:Prepare Suspension Structured Vehicle USP-NF (SSV) according to the USP-NF.Using a pestle and mortar, grind 5 valacyclovir tablets for 25 mg/mL suspension or 10 valacyclovir tablets for 50 mg/mL suspension until a fine powder is produced.Gradually add about 5 mL aliquots of SSV to mortar and triturate powder until paste has been produced, ensuring the powder has been adequately wetted.Continue to add about 5 mL aliquots of SSV to mortar, mixing thoroughly between additions, until a concentrated suspension is produced, to a minimum total quantity of 20 mL SSV and a maximum total quantity of
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