Amiodarone po

Loading with amiodarone can be done in several ways – IV, PO, IV followed by PO, or IV and PO together. The loading regimen employed depends

PO amiodarone 25.7 mg/kg vs. IV amiodarone 3‐5 mg/kg bolus then 10‐15 mg/kg over 24 h No difference in conversion to SR between PO and IV (64% vs. 68%, respectively; p=NS) 223 patients with symptomatic atrial fibrillation on digoxin PO amiodarone 600 mg in3 divided doses vs. IV amiodarone 5mg/kg over

Amiodarone increases PO digoxin serum concentrations by ~70% and IV digoxin by ~17%; measure digoxin levels before initiating amiodarone and reduce PO

Conversion from IV to oral (PO) amiodarone will occur based on patient 50% bioavailability of PO versus IV amiodarone). The primary

PO amiodarone 25.7 mg/kg vs. IV amiodarone 3-5 mg/kg bolus then mg/kg over 24 h. No difference in conversion to SR between PO and IV.

Amiodarone increases PO digoxin serum concentrations by ~70% and IV digoxin by ~17%; measure digoxin levels before initiating amiodarone and reduce PO digoxin

IV to PO conversion of Amiodarone after 48 hours. Special Instructions: If the patient is taking other PO meds then stop the infusion and order 400 mg PO bid.

PO AMIODARONE: COMPARING RISKS. Amiodarone Cardiac Toxicities. Bradycardia. Heart Block ?Hypotension. Acute. Bradycardia. Heart block. QTc

Single dose then continue amiodarone infusion as directed IF selected previously. Then: Continue IV Amiodarone. Amiodarone 400 mg PO TID x 9 days. Amiodarone