Cyanide toxicity nitroprusside

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Actual: Treatment of cyanide toxicity requires the cessation of nitroprusside and, for severe toxicity, use of the cyanide antidote kit. Cyanide toxicity from nitroprusside may be prevented by concomitant administration of sodium thiosulfate infusions.
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Toxicity. The toxicity of nitroprusside is related to its potent antihypertensive effects and the accumulation of toxic metabolites (cyanide, thiocyanate, and methemoglobin). 1. Cyanide toxicity: Nitroprusside combines with hemoglobin and is subsequently metabolized to 5 cyanide ions and cyanmethemoglobin. Cyanide then converts to thiocyanate

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Overdosage of nitroprusside can be manifested as excessive hypotension or cyanide toxicity [see WARNINGS AND PRECAUTIONS] or as thiocyanate toxicity [see

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by MR Holme 2024 Cited by 22Toxicity 1. Cyanide toxicity: Nitroprusside combines with hemoglobin and is subsequently metabolized to 5 cyanide ions and cyanmethemoglobin.

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An early manifestation of cyanide toxicity is increasing dosage requirements to maintain blood pressure control. Metabolic acidosis may not be evident for more than an hour after toxic cyanide levels accumulate. If cyanide toxicity develops, discontinue sodium nitroprusside, and consider specific treatment of cyanide toxicity [see Overdosage ].

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patients whose deaths have been unequivocally attributed to nitroprusside induced cyanide toxicity have been patients who had received nitroprusside

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Hydralazine: compensatory tachycardia, headache, angina, SLE-like symptoms (in slow acetylators), fluid retention. Nitroprusside: Nitroprusside is metabolized to cyanide, and it can lead to cyanide toxicity. Toxicity can appear as little as four hours after initiation of infusion.

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Sodium thiosulfate and hydroxocobalamin have both been empirically used for cyanide toxicity and have specifically been evaluated for cyanide toxicity associated with sodium nitroprusside. Cobinamide is an investigational agent currently being evaluated for efficacy and safety in the treatment of cyanide toxicity.

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cyanide toxicity or as thiocyanate toxicity. o Standard Cyanide treatment is often effective. Sodium nitroprusside infusions at rates

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Overdosage of nitroprusside can be manifested as excessive hypotension or cyanide toxicity or as thiocyanate toxicity. The acute intravenous

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