The cumulative exposure of EXPAREL in these studies is well in excess of the proposed maximum single-dose exposure that is intended in humans.
The maximum dosage of Exparel for adults is ~266 mg, but the maximum mg/kg dosing limit is unknown. The role of Intralipid (ILP, 20%) for
The recommended dose of Exparel for local infiltration in adults is up to a maximum dose of 266 mg (20 mL). The recommended dose of Exparel for interscalene
Maximum infiltration dose: 266 mg (20 mL) Pill medicine is Exparel 1.3% injectable suspension Exparel (bupivacaine liposome) 1.3% injectable
EXPAREL is intended for single-dose infiltration only. EXPAREL should be administered with a 25 gauge or larger bore needle. The maximum dosage of EXPAREL
Via nerve block, patients received 133 mg of EXPAREL, 266 mg of EXPAREL (two times the maximum recommended EXPAREL dose) [see Dosage and Administration (2.3)] or 133 mg of EXPAREL admixed with 50 mg of bupivacaine HCl. In both of these studies the active comparator was 50 mg of bupivacaine HCl.
The recommended dose of Exparel in pediatric patients is 4 mg/kg (up to a maximum of 266 mg) as a single-dose infiltration. The dose is
EXPAREL is intended for single-dose infiltration only. EXPAREL should be administered with a 25 gauge or larger bore needle. The maximum dosage of EXPAREL should not exceed 266 mg (20 mL, 1.3% of undiluted drug). Do not administer EXPAREL if the product is discolored. Do not administer EXPAREL if it is suspected that the
The maximum dose of EXPAREL should not exceed 266 mg. The recommended dose of EXPAREL for patients aged 6 to 17 years old is 4 mg/kg, up to a maximum of 266 mg. The recommended dose of EXPAREL in adults for interscalene brachial plexus nerve block, sciatic nerve block in the popliteal fossa, and adductor canal is 133 mg. The
That said, keep up the story-telling. I'll be watching for part 2.