the treatment of acyclovir-resistant mucocutaneous HSV infections in immunocompromised patients acyclovir-resistant hsv infections.
Treatment for acyclovir-resistant genital herpes: Foscarnet (40 The following are regimens for acyclovir‐resistant HSV in adult HSV‐
In this review we will discuss acyclovir mode of action, mechanisms of resistance, prevalence of resistance, and alternative antiviral treatments for acyclovir resistant HSV infections. Keywords: Acyclovir; Acyclovir resistance; Herpes simplex virus; Immune-privileged sites; Immunocompromised; Prevalence.
Foscarnet was administered five to seven days following acyclovir in these cases for management of acyclovir-resistant HSV. Acyclovir-resistant HSV has a known and consistent prevalence of about 0.3% in immunocompetent patients [19, 20]. This delay in initiating a definitive treatment could explain the poorer outcomes observed with this treatment.
For HSV that is resistant to acyclovir or ganciclovir, cidofovir and foscarnet are potential alternative treatments. These drugs do not require phosphorylation
acyclovir and valacyclovir being the gold standard treatments due to their efficacy and safety profile . acyclovir-resistant HSV
by RG Kost 2024 Cited by 195Acyclovir resistance has not been a problem to date in the treatment of immunocompetent people with HSV infection. Acyclovir-resistant HSV is
acyclovir or valacyclovir is typically switched to a treatment dosing. However, resistance can occur in some patients. Acyclovir-resistant HSV infection is
Acyclovir for the treatment of herpes simplex (HSV) infections [23] . Treatment of acyclovir-resistant herpes simplex virus infection in patients with AIDS.
Comments
Gavin explains , For instance, an antibiotic, if you take the same antibiotic every infection, your body will stop responding to it.
Antibiotics stop working because the dose is too low or the treamement is too short a time not because of frequent use. During treatment, the most resistant bacteria are the last to die so any bacteria that survive a course of treatment are now selected to build the next generation of stronger and more resistant bacteria.
The solution is exactly the opposite of Gavin's statement i.e. more antibiotic for a longer time to ensure all bacteria are killed.