Lorazepam's anticonvulsant and CNS depressant properties are useful for the treatment and prevention of alcohol withdrawal syndrome. In this setting, impaired liver function is not a hazard with lorazepam, since lorazepam does not require oxidation, in the liver or otherwise, for its metabolism.
Lorazepam's anticonvulsant and CNS depressant properties are useful for the treatment and prevention of alcohol withdrawal syndrome. In this setting, impaired liver function is not a hazard with lorazepam, since lorazepam does not require oxidation, in the liver or otherwise, for its metabolism.
Lorazepam is metabolised in the liver by conjugation into inactive lorazepam-glucuronide. The effect of intravenous premedication with lorazepam (Ativan)
drugs like Lorazepam have occasionally affected blood and liver function. What Lorazepam 0.5mg Tablet looks like and contents of the pack. Lorazepam
In this setting, impaired liver function is not a hazard with lorazepam, since lorazepam does not require oxidation, in the liver or otherwise, for its
Since the liver is the most likely site of conjugation of lorazepam and since excretion of conjugated lorazepam (glucuronide) is a renal
Lorazepam is broken down (metabolized) in the liver. But unlike many other benzodiazepines, lorazepam metabolism doesn't involve liver proteins
Lorazepam and diazepam are also metabolized, or processed, in the body differently. Lorazepam is metabolized in the liver by a process known as glucuronidation.
Lorazepam is metabolized in the liver by conjugation into inactive lorazepam-glucuronide. This metabolism does not involve liver oxidation, so is relatively unaffected by reduced liver function. Lorazepam-glucuronide is more water-soluble than its precursor, so gets more widely distributed in the body, leading to a longer half-life than lorazepam.
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