Taking diphenhydramine (Benadryl) and mirtazapine (Remeron) is probably not a safe or ideal drug combination.
Doctors may prescribe: antihistamines, such as diphenhydramine (Benadryl) and hydroxyzine antidepressants, such as mirtazapine (Remeron)
Why are mirtazapine and benadryl incompatible with one another? Both mirtazapine and benadryl can act incompatibly because of their different mechanisms of action. Mirtazapine (Brand name: Remeron) is an antidepressant. It does not belong to any typical class of antidepressants and its mechanism of action is different from SSRIs and SNRIs.
diphenhydramine (Benadryl), hydroxyzine (Atarax, Vistaril); Alpha-2 Atypical antidepressants: mirtazapine (Remeron), trazodone
Benadryl (Diphenhydramine) Chlortrimetron (Chlorpheniramine) Claritin Mirtazapine (Remeron) Nefazodone (Serzone) Nortiptyline (Pamelor, Aventyl)
In our latest question and answer, the pharmacist discusses whether or not it is safe to take Benadryl (diphenhydramine) with mirtazapine.
Can I take Advil with Coricidin HBP Chest and Cough medicine? READ MORE Taking Benadryl With Mirtazapine. I take mirtazapine for depression
Diphenhydramine (found in Benadryl); Hydroxyzine (found in Vistaril) Prozac (fluoxetine); Remeron (mirtazapine); Risperdal (risperidone)
However, this antidepressant can interact with other medications. This blog will cover the safety and efficacy of the concomitant use of mirtazapine and benadryl. Can you use mirtazapine and Benadryl together? No, it is not suitable to use mirtazapine and benadryl together. This is not an ideal combination and should only be used if absolutely
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